Nausea and Vomiting
| Mechanism | Drug | Dose | Side Effects |
|---|---|---|---|
| 5-HT3-Receptor Antagonist | Ondansetron |
0.1 - 0.2mg/kg q6-8h PO/IV/SL (max 4-8mg/dose) |
Nausea and constipation at higher doses *QTc prolonging |
| D2-Receptor Antagonist | Metoclopramide |
0.1 - 0.2mg/kg q6h PO/PR/IV (max 5-10mg/dose) |
Extrapyramidal Symptoms *QTc prolonging |
| Haloperidol |
0.01 - 0.02mg/kg q8h (max 1-2mg/dose) |
||
| H1-Receptor Antagonist | Diphenhydramine |
0.5 - 1mg/kg q6h PO/IV (max 50mg) |
Anticholinergic Side Effects |
| AChM-Receptor Antagonist | Scopolamine |
0.33 - 0.5mg/day TD Adolescents: 1.5mg q72h |
|
| D2/5HT2/5HT3/H2-Receptor Antagonist | Olanzapine |
1.25 - 2.5mg PO daily (max 5mg/dose) |
Extrapyramidal Symptoms *QTc prolonging |
| Benzodiazepine | Lorazepam |
0.02 - 0.05mg/kg q6h PO/PR/IV (max 2mg/dose) |
Drowsiness |
| Neurokinin-I Receptor Antagonist | Aprepitat | 125mg x 1, then 80mg qd x 2-4d | Constipation, headaches, fatigue, sinus tachycardia |
| Cannabinoid-Receptor Antagonist | Dronabinol | 0.05 = 1mg/kg PO q8-12h | Dizziness, dysphoria, hallucinations, arterial hypotension |
| Steroids | Dexamethasone |
0.1mg/kg q6-8h (max 16mg/day) |
Weight gain, adrenal suppression, immunosuppression |